Benefits Of CBD :
Based On Academic Research

Best CBD For Anxiety, Depression & Stress – 2021 Brands

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History of CBD

Cannabis has been used around the world for centuries and the purpose for its use has varied throughout that time. However, the utilization of cannabis for medicinal purposes has been consistent. Starting with the Chinese around 2900 B.C., many civilizations have transcribed their use of cannabis for a variety of conditions, from joint pain and muscle spasms to conditions such as gout and malaria. Source: History of cannabis and its preparations in saga, science, and sobriquet.
Russo EB
Chem Biodivers. 2007 Aug; 4(8):1614-48.

Around 1000 year B.C., more parts of the cannabis plant started to be used medicinally in India. The female plant’s flowers were utilized and three different preparations of cannabis with varying degrees of potency were developed.
Source: The religious and medicinal uses of Cannabis in China, India and Tibet.
Touw M
J Psychoactive Drugs. 1981 Jan-Mar; 13(1):23-34.

benefits of CBD

The strongest scientific evidence is for its effectiveness is in treating epilepsy syndromes, such as Dravet syndrome and Lennox-Gastaut syndrome (LGS), which typically don’t respond to antiseizure medications. In numerous studies, CBD was able to reduce the number of seizures, and, in some cases, it was able to stop them altogether. Trials showed CBD significantly reduced seizure frequency by almost 44% in most people. This is the one FDA approved use.

Anxiety disorders are among the most common psychiatric conditions. It’s estimate that 19.1% of adults in the U.S. experienced an anxiety disorder in the past year, and more women experience anxiety than men.

CBD has broad therapeutic properties across a range of neuropsychiatric disorders, stemming from diverse central nervous system actions. In recent years, CBD has attracted increasing interest as a potential anxiolytic treatment. CBD has a broad pharmacological profile, including interactions with several receptors known to regulate fear and anxiety-related behaviors. Existing preclinical evidence strongly supports the potential of CBD as a treatment for anxiety disorders and reducing long term effects of stress. CBD interacts with the cannabinoid type 1 receptor (CB1R), the serotonin 5-HT1A receptor, and other receptors in the brain that regulate fear and anxiety-induced behaviors.

Researchers found that 300–600 mg of CBD significantly reduced anxiety symptoms in 57 adult males. 300 mg showed most successful in dosage.
Studies have presented evidence that established CBD as an effective treatment for numerous types of anxiety disorders, including:

  • generalized anxiety disorder (GAD)
  • post-traumatic stress disorder (PTSD)
  • panic disorder (PD)
  • obsessive-compulsive disorder (OCD)
  • social anxiety disorder (SAD)

The VA San Diego Medical Center is conducting the first funded clinical trial of the effects of CBD with Veterans suffering from PTSD.

The effects of orally administered CBD, such as oils, edibles, or capsules, begin working within 30 minutes to 2 hours. Smoking or vaping CBD oil or cannabis buds results in more immediate effects.

CBD has been proven to block certain enzymes that trigger inflammation in the body. Animal studies showed that topical CBD applications relieve pain and inflammation associated with arthritis. The topical application of CBD is beneficial for this type of relief.

Evidence points toward a calming effect for CBD in the central nervous system. Some research indicates that the cannabinoid CBD may interact with specific receptors, potentially affecting the sleep/wake cycle. The two primary receptors identified are CB1 and CB2.
There are multiple studies that showed evidence of improved sleep. In a large case series of 72 people, 48 patients (66.7%) reported an improvement in sleep. 31% of people taking CBD for other conditions reported improved sleep with CBD.

Most testing is limited to animals; however, more and more studies are being reported with human trials. Most paid studies include combination that includes THC combined with CBD.
Animal studies have shown that CBD has a positive effect on serotonin levels in the brain, and serotonin. Low levels of serotonin are thought to play a key role in mood as well as pain.

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